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 Pharmacology/Toxicology



Dr. ORISH EBERE ORISAKWE

 

NAME: ORISH EBERE ORISAKWE
NATIONALITY: Nigerian

B.Sc. (Hons) Biochemistry, University of Nigeria, Nsukka (1984)
M.Sc. Pharmacology/Toxicology, University of Lagos, Nigeria (1987)
M.Phil. Pharmacology/Toxicology, University of Lagos, Nigeria (1990)
Ph.D. Pharmacology/Toxicology, University of Nigeria, Nsukka (l997)

Nnamdi Azikiwe University
Nnewi Campus
P.M.B.5001, Nnewi,
Anambra State, Nigeria
Tel: +234(0)8035510063
Fax: +234-046-460124


RECORDS: EMPLOYMENT

:: 1987-1988 Research Assistant:
College of Medicine, University of Lagos
Idiaraba, Nigeria.

Job Description:
I was involved in rotational posting in all the ongoing researches in the Department of Pharmacology and Toxicology. I worked in the following Laboratories in the department:

Ethnopharmacology
Endocrine / Metabolism
Chemotherapy
Pharmacokinetics
Toxicology

I was also involved in the teaching of Pharmacology to Pharmacology, Physiology, Dentistry, Pharmacy and Medical Students.

:: 1988 - 1990 Graduate Research Assistant
Toxicology Research Laboratories, College of Medicine, University of Lagos, Idiaraba, Nigeria.

Job Description: I was permanently attached to the Toxicology Research Laboratories where I was involved in consultancy services, organization of seminars and workshops on Environmental Toxicology. I was also involved in supervision of undergraduate.

:: 1990-1993 Lecturer:
Department of Pharmacology, Nnamdi Azikiwe University, Nnewi Campus.

Job Description:
I was involved in teaching and research.

:: 1994-present Senior Lecturer
Department of Pharmacology, Nnamdi Azikiwe University, Nnewi Campus.

Job Description: I have been teaching undergraduate and postgraduate students. I have also been involved in active supervision of postgraduate students and interdepartmental supervision of postgraduate students. My current research interests include:

Reproductive Toxicology: Testicular  toxicity  of metals and heavy
  metal in Nigerian traditional herbal remedies.
Reproductive toxicology of petroleum products .
Ecotoxicology of some rivers in Nigeria.
Water  and  soil  qualities  of  highly  industrialised  cities in
  Nigeria. etc.

As Head, Department of Pharmacology 1994 - 2000, 1 was involved in day-to-day administration of the department. Other positions of responsibility bordering on trust and honesty were entrusted to me. My list of publications (more than 90 articles) spread out in notable journals around the globe.

PERSONAL DETAILS

SURNAME: Orisakwe
OTHER NAMES: Livinus Orish Ebere
GENDER: Male
NATIONALITY: Nigerian
PLACE OF BIRTH: Lagos, Nigeria
DATE OF BIRTH: March 1, 1962
MARITAL STATUS: Married
NUMBER OF CHILDREN: 4
NEXT OF KIN:
Dr (Mrs.) Chinna N. Orish
Nnamdi Azikiwe University Teaching Hospital
Nnewi, Anambra State, Nigeria.

SCHOOLS ATTENDED WITH DATES

(1) University of Nigeria, Nsukka (1980 - 1984)
(2) University of Lagos, Nigeria (1986 - 1990)
(3) University of Nigeria, Nsukka (1992 - 1997)

ACADEMIC QUALIFICATIONS

(1) B.Sc (Hons) Biochemistry
(2) M.Sc Pharmacology/Toxicology
(3) M.Phil. Pharmacology /Toxicology
(4) Ph.D. Pharmacology/Toxicology

BIOGRAPHICAL REFERENCE LISTINGS/AWARDS

* Marquis Who’s Who in the World.
* IBC Nominated, Outstanding People of the 20th Century (CAMBRIDGE)
* Marquis Who’s Who in Medicine and Healthcare
* American Biographical Institute, Research Board of Advisors.
* American Biographical Institute, MAN OF THE YEAR 2000.
* American Biographical Institute, International Directory of
  Distinguished Leadership,

HALL OF FAME

* Marquis Who’s Who in Science and Engineering 2000.
* American Biographical Institute Medal Award.
* International  Peace  Prize,  United  Cultural  Convention  of the
  United States of America
* American Biographical Institute, MAN OF THE YEAR 2005.

MEMBERSHIP OF INTERNATIONAL BODIES

(1) American Association for Advancement of Science (AAAS)
(2) Society of Toxicology, (SOT), Washington, USA
(3) New York Academy of Science (NYAS)
(4) African  Society  for  Toxicological  Sciences  (ASTS), Nigerian
    Coordinator 2000-2002
(5) AFRICACLEAN (World  Bank  Assisted  Group  for the use of Leaded
    Gasoline in sub Saharan Africa), Nigerian Facilitator 2000-date
(6) Fellow, Natural Science & Engineering Research Council, Canada
(7) International Society for Study of Xenobiotics, USA

MEMBERSHIP OF LOCAL BODIES

(1) Consultant, Biokinetic Research Group
(2) Member, West African Society for Pharmacology (WASP).

EDITORIAL BOARD AND REGISTRATION

(1) Editorial Board Member - Associate Editor for Africa Region “International Journal of Environmental Research and Public Health. 1SSN 1660-4601” Molecular Diversity Preservation International, Basel, Switzerland.

(2) Editorial Advisory Board Member-“Recent Patents on Anti-infective Drug Discovery” Bentham Science Publishers Ltd, P.O. Box 640310, San Francisco, CA 94164-0310, USA.

(3) Consulting Editor , American Biographical Institute, 5126 Burke Oak Circle, Raleigh NC 27612 USA.

(4) External Reviewer: Environment, Lancaster, UK.

(5) External Reviewer: Journal of Raw materials Research, Official organ of Raw materials Research and Development council, Abuja , Nigeria.

(6) External Reviewer: Reproductive Toxicology , Louisville USA

(7) External Reviewer: Toxicology and Environmental Chemistry, Environmental Chemistry and Ecotoxicology, University of Bayreuth, Germany

RESEARCH COLLABORATORS

Professor Paul-Bernard Tchounwou
Professor and Director of Environmental Science
NHI-Center for Environmental Health
Jackson State University. USA
Email: paul.b.tchounwou@jsums.edu
URL: http://stallion.jsums.edu/~envsci/

Hoffman Moka Lantum MD,
PhD Toxicologist
Unit Director
Biochemical & Analytical Toxicology
Health and Environmental Laboratories
Eastman Kodak Company, USA.
Hoffman.lantum@kodak.com

Dr Amadou Diouf Toxicologist
Toxicologue Fac. Medecine, UCAD
Dakar, Senegal.
E-mail: amdiouf@refer.sn

Prof Jerome Nriagu
School of Public Health
Department of Environmental &Industrial Health
University of Michigan
USA
Email:jnriagu@sph.umich.edu

Travel Fellowships or Sponsorship to International Conferen/workshop

(1) Name of Conference/Theme:
    Environmental Health Conference/Environmental
    Health Needs and Research Opportunities for West Africa.

Sponsor:
Environmental and Occupational Health Sciences Institute, EOHSI, USA National Institute of Environmental Health Sciences, NIEHS, USA; University College, Rutgers, USA.

Role in Conference:
Resource person/Symposium speaker

Date/Place:
January 3-6, 2001 / University of Legon, Ghana, West Africa

(2) Name of Conference/Theme:
    34th Annual Symposium, Society of Toxicology, Canada (STC)

Sponsor: Toxicology Research Division, Health Canada

Role in Conference: Attendee

Date/Place: Dec 6 & 7, 2001/ Holiday Inn, Montreal, Quebec, Canada

(3) Name of Conference/Theme:
    Radiation Safety Workshop

Sponsor: Canadian Nuclear Commission

Role in Workshop: Trainee

Date/Place: Dec 4 2001, Banting Research Centre, Ottawa, Canada

(4) Name of Conference/Theme:
   
World Conference Antiinfectives/ Paul Ehrlich Symposium

Sponsor: World Conference on Drugs and Antiinfectives (WCDA) [Part Sponsorship]

Role in Workshop: Attendee

Date/Place: September 6- 12, 2004/ Nurenberg Germany

(5) Name of Conference/Theme: 7th International ISSX meeting

Sponsor: International Society for the Study Xenobiotics [Part Sponsorship]

Role in Workshop: Attendee/ Presentation of paper.

Date/Place: August 29-September 2 / Vancouver, Canada

(6) Name of Conference/Theme:
   First International Symposium on Recent Advances in Environmental

Sponsor: Center Environmental Health- Environmental Science PhD programme

Role in Workshop: Symposium speakers.

Date/Place: September 19- 22, 2004/ Jackson State University, Mississippi.

(7) Name of Conference/Theme: 44th Annual SOT Meeting

Sponsor: African Society for Toxicological Sciences/African Education ,Initiative (NEF).

Role in Workshop: Attendee/ Presentation of paper.

Date/Place:
March 6-10, 2005/ Louisiana , New Orleans.

(8) Name of Conference/Theme: 8th International ISSX meeting

Sponsor: International Society for the Study Xenobiotics
         [Part Sponsorship]

Role in Workshop: Attendee/ Presentation of paper.

Date/Place: October 23-October 27 / Maui, Hawai, USA.

RESEARCH AWARD WON

(a) Canadian Government Laboratory Visiting Fellow 2001-2002.
(b) Nnamdi Azikiwe University, Senate Grant 1995/96.


(c) EVALUATION OF THE MEDICINAL ROLE OF LOCALLY PRODUCED CARBON BLACK”
Sponsor: RAW MATERIALS RESEARCH AND DEVELOPMENT COUNCIL, MAITAMA, ABUJA, NIGERIA
Amount: N1,954,150 (12/2003 - 12/2004).

(d) Heavy metal hazards of Nigerian traditional remedies and investigations of chronic organ effects.
Sponsor NATIONAL AGENCY FOR FOOD AND DRUG ADMINISTRATION AND CONTROL (NAFDAC) ABUJA, NIGERIA.
Amount: N4,136,616.00. (07/2004 -2005).

(e) Society of Toxicology- AstraZeneca Award (2005) on outstanding qualifications as a senior scientist and practice of toxicology, FROM INTERNATIONAL UNION OF TOXICOLOGY

OTHER PROFESSIONAL EXPERIENCES

1. Resource person: Toxicology Internship Program, African Education Initiative, Nduaka Educational Foundation (USA) and National Institute of Pharmaceutical Research and Development, Abuja, Nigeria.( www.nef3.org)

2. Accredited environmental consultant to Federal Ministry of Environment of the Federal Republic of Nigeria

3. Accredited environmental consultant to Directorate of Petroleum Resources, Nigerian National Petroleum Corporation

LIST OF PUBLICATIONS
(Country in parenthesis indicates where article was published)

1. Akintonwa. A., Orisakwe O.E. (1988). Adsorption of metronidazole and tinidazole to activated charcoal and effect of magnesium sulphate. Vet. Hum. Toxicol 30 (6): 556-558. (U. S. A).

2.
Akintonwa A., Orisakwe L. O.E. (1990). Effect of activated charcoal on chloroquine absorption in man. Nig. J. Physiol. Sci. 6 (1): 18-27. (NIGERIA).

3. Akintonwa A., Orisakwe L. O. E (1990). Effect of saline cathartics on the absorption on sulphamethoxazole to activated charcoal. Arch. Int. Pharmacology 304: 290- 294. (BELGIUM).

4. Orisakwe L.O.E., Akintonwa A. (1991). Comparative adsorption of chloroquine, mefloquine, isoniazid to activated charcoal and locally produced carbon black. (220).
West Africa J. Pharmac Drug Res. 4 (Supplement): 35-37. (WEST AFRICA).

5. Orisakwe, L.O.E., Akintonwa A. (1991). Effect of Na2S04 on adsorption of chloroquine and mefloquine to activated charcoal. East African Med..J. 68 (6). 420-424 (KENYA).

6. Orisakwe L.O.E., Akintonwa (1991). In vitro adsorption studies of isoniazid. Hum. Exp. Toxicol. 10: 133- 135 (U.K.).

7. Orisakwe L.O.E., Akintonwa A. (1991). Effect of activated charcoal on quinine absorption in man..Nig. J. Physiol. Sci. (1): 49-53. (NIGERIA).

8 Orisakwe L.O.E., Akintonwa A. (1990).The adsorption of quinine and quinidine to activated charcoal with and without MgSO4. Vet. Hum. Toxicol. 32 (6): 567-568. (U.S.A.).

9 Orisakwe L.O.E. (1992). Safety warning and first aid instructions on consumer and pharmaceutical products in Nigeria. Are they adequate? Hum. Exp. Toxicol. 11(6): 546 548. (U.K).

10 Orisakwe L.O.E. (1994). Activated charcoal. Is Failure to use it negligence or ignorance?
South Med.. J. 82 (27): 165- 168 (U.S.A.).

11 Orisakwe L.O.E., Obi N. (1993). In vitro and in vivo absorption studies of diazinon. Hum. Exp. Tox.. 13: 133-135. (U.K).

12. Orisakwe O.E. (1992). Use of activated charcoal to treat poisoning. Trop. Doc.176-177. (U.K).

13 Orisakwe O.E., E. Ogbonna (1993). Effect of saline cathartics on gastro-intestinal transit time of activated charcoal. Hum. Exp. Toxicol. 13: 403405. (U.K).

14 Orisakwe O. E. (1992). Negligence of activated charcoal due to lack of current information. Israel Med.. J. 28 (10): 751-752. (ISRAEL).

15. Orisakwe O.E., Akah P. A., Orish C.N. (1994). Prevalence of parental administration of drugs to children before coming to the hospital. Trop. Doc. 24:182-183. (U.K.).

16. Nwobodo E., Okonkwo C., Orisakwe O.E., Obi, E. (1995).
Menarche in Nigeria Ibos. Orient J. Med.. 7(2): 23-25. (NIGERIA).

17 Orisakwe O.E., Dioka E.C., Orish C.N., Okpogba A.N. (1994). Charcoal and rifampicin pharmacokinetics. Amer. J. Therap. 2: 68- 70. (U.S.A.)

18. Orisakwe O.E., Ofoefule S.I., Dioka,C. E., Ufearo C. S., Nwobodo E.O. (1995). Carbon Black: A possible role in poison management. Tokai J. Exp. Clin.. Medicine. 20 (2): 67- 70. (JAPAN).

19. Ufearo C.S., Orisakwe O.E. (1995).Restoration of normal sperm characteristics in hypoprolactinemic infertile men treated with metoclopamide and exogenous human prolactin. C1in.. Pharm.. Ther. 58 (3): 354-359. (U.S.A.).

20. Orisakwe O.E., Nwobodo E.O ., Dioka C. E., Okogba A.N. (1995).Effect of headaches on working ability. An epidemiological survey of automobile industries. Nig. Med.. J. 29 (2): 56-58. (NIGERIA).

21. Orisakwe O.E., Afonne O.J., Dioka C.E. (1996). Preliminary investigation of Synclisia scabrida as a folklore medicine in Nigeria. BMSA 7(3):1-5. (JAPAN).

22. Orisakwe O.E. Afonne O.J., Dioka C.E. (1996). A papaverine-like activity of Synclisia scabrida in Nigerian folklore. BMSA 8(3): 1-5. (JAPAN).

23. Ufearo C. S., Orisakwe O. E., Ogamba J.O., Maduka S.O. (1996). Evidence for prolactin participation in the control of male fertility. J. Med. Lab. Sci. 5: 148-152. (NIGERIA.).

24. Orisakwe O. E., Afonne O. J., Dioka C. E., Ufearo C. S., Ofoefule S.I. (1996). Investigation into the oestrogen-like activity of Synclisia scabrida. Fitoterapia. LXVII (5): 469- 471. (ITALY).

25. Orisakwe O.E., Dioka C. E., and Ofoefule S.I., (1996). A comparative review of poisoning in Nigeria. J. W. Afr. Pharm. 10 (2): 53-55. (WEST AFRICA).

26. Orisakwe O.E., Afonne O.J., Dioka C. E., Ufearo C.S., Okpogba A.N., Ofoefule S.I. (1996). Some pharmacological properties of Synclisia scabrida II. Indian J. Med. Res. 103: 282-284. (INDIA).

27. Orisakwe O.E., Dioka C.E., Nwobodo E. O., Okonkwo V. C., Anike I.C., Enendu A. O. (1996). Respiratory abnormalities associated with occupational exposure to particulate insults in “Okada” (Motorcycle ) operators in Nnewi. Nig. Med.. Pract. 32(3/4): 36-38. (NIGERIA).

28. Nwobodo E., Orisakwe O. E. Okonkwo C., Dioka C. E., Amilo G. (1997). Dysmenorrhea amongst school girls and treatment. Orient J. Med. 8 (4): 166-169. (NIGERIA).

29. Orisakwe O. E., Dioka C. E., Okpogba A.N., Orish C.N., Ofoefule S.I. (1996). Effect of activated charcoal on rifampicin absorption in man. Tokai J. Exp. Clin. Medicine 21 (1): 51-54. (JAPAN).

30. Orisakwe O.E., Ofoefule S. I. (1996). Plasma and saliva concentration of rifampicin in man after oral administration. Tokai J. Exp. Clin. Med. 21 (1): 45-49. (JAPAN).

31 Ofoefule S.1., Orisakwe O.E., 1bezim E.C., Esimone C.O. (1998). Mechanism of nifedipine release from sustained release tablets formulated with some polymeric materials. Boll. Chim. Farm. 37 (6): 223-227. (ITALY).

32. Orisakwe O.E., Chilaka K.C., Okpogba A.N. (1997). Plasma levels of aluminum after ingestion of achara tea (Cympogopon citratus) in human volunteers. Asian Pacific J. Pharm. 13, 79-82. (SINGAPORE/JAPAN).

33 Ibezim E.C.,Ofoefule S.I., Ejeahalaka C.N.C Orisakwe O.E. (1999). In vitro adsorption of ciprofloxacin on activated charcoal and talc. Amer. J.Ther. 6: 199-201. (U.S.A).

34 Ofoefule S.I., Nwankwo C, Chukwu A,Orisakwe O.E. (1998). In vitro properties of ciprofloxacin suppositories formulated with glycerogelatin and theobroma oil bases. Boll. Chim. Farm. 137 (9): 685-688 (ITALY).

35 Akah P.A., Orisakwe O. E., Gamaniel K.S. (1998). Evaluation of Nigerian traditional medicine II: effect of some Nigeria folk remedies on peptic ulcer. J. Ethnopharmac. 62:123- 127 (NETHERLAND /USA).

36 Akah P.A., Orisakwe O.E., Nwafor S.V., Gamaniel K. S. (1998). Prospects of natural plant product as antiulcer agents. J. Pharm. Res Dev. 3 (2) 57- 62 (NIGERIA).

37. Ofoefule S.I., Orisakwe O.E., Obi E. (1996). A procedural update on .laboratory diagnostic test and current treatment protocols for immunologically mediated infertility in the male. Indian. J. Hosp. Pharm. (Accepted for publication) (INDIA).

38. Orisakwe O.E., Ofoefule S.I., Nwobodo E. (1996). Snuff, harmless substitute for tobacco? Indian. J. Hosp. Pharm. (Accepted for publication). (INDIA).

39. Ibezim E., Ofoefule S. I., Orisakwe O. E. (1996). A comparative study of the in vitro adsorption of some drugs on activated charcoal. J. Univ. Sci. Tech. (Accepted for publication) (GHANA).

40. Orisakwe O.E., Obi E., Amilo G., Dioka C. E., Afonne O.J., Ufearo C. S. (l997). Sodium and potassium levels and label review studies of Nigeria spices. Indian J. Nutr. Diet. 37:146-150. (INDIA).

41 Orisakwe O.E., Dioka C. E., Ufearo C. S. (1999). The effect of ovarian steroid hormones on the prostaglandins metabolism in the rat lung. Afr. J. Med. Pharm. Sci 1:52-55 (NIGERIA).

42 Orisakwe O. E., Obi E., Asomugha A .L. (1999). Use of neutrophil from cardiac puncture and wounds smear as ulcer markers. Nig. J. Med. Res. 3:4 (NIGERIA) .

43 Orisakwe O. E.,Orish C.N., Egenti L. (2000). Childhood non drug poisoning in
Nnewi, Nigeria. Trop Doc.) 30 209-211 (UK).

44 Ofoefule S.I., Orisakwe O.E., et al (2004). Bioavalability of metronidazole in rabbits after administration of rectal suppository. Amer. J. Ther 11 (3) 190-193 (U.S.A).

45. Orisakwe O.E., Asomugha R., Afonne O. J., Obi E., Chilaka K.C., Dioka C. E. (1999). Effect of industrial effluents on soil and water qualities in Nnewi, Nigeria. J. Health Sci. 45 (4): 177-183 (JAPAN).

46 Orisakwe O.E., Chilaka K.C., Afonne O.J., Obi E., IIondu N. (1999). Evaluation of the developmental toxicity of amlodipine besylate in mice. J. Health Sci. 46 (1): 42-45 (JAPAN).

47 Afonne O. J., Orisakwe O. E., Ndubuka G.I., Akumka D.D., Ilondu N.D.A. (2000). Zinc protection of mercury-induced hepatic toxicity in mice. Biol. & Pharm. Bull. 23(3): 305-308 (JAPAN).

48. Ilondu N., Orisakwe O.E., Ofoefule S.I., Afonne O.J., Obi E., Chilaka K. C.,Orish C. (2000). Pharmacokinetics of diethylcarbamazine: Prediction by concentration in saliva. Biol. & Pharm.. Bull. 23 (4): 443-445 (JAPAN).

49. Orisakwe O.E., Ilondu N.D.A., Afonne O.J., Ofoefule S.I., Orish C.N. (2000). Acceleration of body clearance of diethylcarbamazine by oral activated charcoal. Pharm. Res. 42 (2): 167-170. (ITALY).

50. Orisakwe O.E., Akumka D.D., Afonne O. J., Gamaniel K.S. (2000). Investigation into the pharmacological basis for folkloric use of Bonny light crude oil in Nigeria. Indian. J. Pharm. 32:231-234 (INDIA).

51. Afonne O.J., Orisakwe O.E., Obi E., Orish C., Akumka D. D. (2000). Some pharmacological properties of Synclisia scabrida III. Indian J. Pharm. 32:239-241 (INDIA).

52. Obi E. Emeh J.K., Orisakwe O.E., Afonne O.J., Ilondu N.A., Agbasi P.U. (2000). Invesigation of the biochemical evidence for the antiulcerogenic activity of Syncliscia scabrida. Indian J. Pharm.32: 381-383 (INDA).

53. Ofoefule S.I., Orisakwe O. E., Onyengba O. (2000). Effect of pefloxacin on urinary and salivary concentrations of isoniazid (INH) in six healthy female volunteers.
Amer. J. Ther. 7(5): 313-316 (U.S.A.)

54. Orisakwe O.E., Afonne O.J., Nwobodo E., Asomugha L., Dioka C.E. (2001). Low- dose mercury induces testicular damage in mice which is protected by zinc. Eur. J. Obst. Gyn. Rep. Biol. 95(1) : 92-96 (NETHERLAND).

55. Ofoefule S.I., Onuoha C., Okonta M.J., Udeogaranya M., Orisakwe O.E. (2001). Effect of activated charcoal on isoniazid absorption in rabbits. Bolletino Chimico Famaceutico 140 (3) 183-186 (ITALY).

56. Orisakwe O.E., Obi E., Emeh J. K. (2000). Antiulceration of Synclisia scabrida. Neutrophil: An alternative ulcer marker? Asian Pacific Journal 15 (4); 77-81 (JAPAN).

57. Orisakwe O.E., Ilondu N.D.A., Afonne O. J., Ofoefule S.I. Orish C.N. (2001). Effect of activated charcoal on diethylcarbamazine absorption in human. Am J Ther 8(1): 7-9
(U. S. A.).

58. Orisakwe O.E., Agbasi P.U., Afonne O.J., Ofoefule S.I., Obi E., Orish C.N. (2001). Rifampicin pharmacokinetics with and without ciprofloxacin. Am. J. Ther. 8(3): 151-153 (U. S. A.).

59. Agbasi P.U., Orisakwe O.E., Obi E., Ofoefule S.I., Ilondu N.A., Afonne O.J. (2001). Effect of sulphate cathartics on adsorption of rifampicin to activate charcoal. Indian J. Pharmac Sci. (July-August): 328-3330 (INDIA).

60. Ofoefule S.I., Obodo C.E., Orisakwe O.E., Ilondu N.A., Afonne O.J., Maduka S.O., Anusiem C.A., Agbasi P.U. (2001). Some plasma pharmacokinetic parameters of isoniazid (INH) in the presence of a fluoroquinolone antibacterial agent. Am. J. Ther. 8(4): 243-246 (USA).

61. Ofoefule S.I., Obodo C.E., Orisakwe O.E., Afonne O.J., Ilondu N.A., Agbasi P.U., Anusiem C.A., Maduka S.O., Ilo C.E. (2002). Salivary and urinary excretion and plasma-saliva concentration ratio of isoniazid (INH) in the presence of co-administered ciprofloxation (CP). Am. J. Ther. 9 (1): 15-18 (USA).

62.Orisakwe O.E., Agbasi P.U., Ofoefule S.I., Ilondu N.A., Afonne O.J., Anusiem C.A. Ilo E., Maduka S.O. (2004). Effect of pefloxacin on the urinary excretion of rifampicin. American Journal of Therapeutics 11(1) 13-16 (USA).

63. Orisakwe O.E., Asomugha R., Obi E., Afonne O.J., Dioka C.E., Akumka D.D., Ilondu N.A. (2001). Ecotoxicological study of the Niger-Delta area of the River Niger. Bull. Environ. Contam. Toxicol. 66(4): 548-552 (USA).

64. Orisakwe O.E., Afonne O.J., Agbasi P.U., Ilondu N.A. Ofoefule S.I. Obi E (2001). Adsorptive capacity of activated charcoal for rifampicin with and without sodium chloride and sodium citrate. Biol. Pharm. Bull. 24 (6): 724-726 (JAPAN).

65. Chude M.A., Orisakwe O.E., Afonne O.J., Gamaniel K.S., Vongtau O.H., Obi E. (2001). Hypoglycemic effect of the aqueous extract of Boerhavia diffusa leaves. Indian J. Pharm. 33: 215-216 (INDIA).

66. Afonne O.J., Orisakwe O.E., Obi E., Dioka C. E., Ndubuka G. I. (2001). Nephrotoxic actions of low-dose mercury in mice: protection by zinc. Arch. Environ. Health 57(2): 98-102 (U.S.A.).

67. Orisakwe O. E., Oluboyo A., Ofoefule S., Obi E., Ilondu N., Afonne O.J., Agbasi P., Chiroma D.H. (2001). Adsorption studies of artesunate: Evaluation of saline cathartics as additive in management of artesunate poisoning. J. Health Sci. 47(5): 1-4 (JAPAN).

68. Afonne O. J., Orisakwe O.E., Ekanem I A., Akumka D.D. (2002). Zinc protects chromium-induced testicular damage in mice. Indian J. Pharm. 34: 26-31 (INDIA).

69. Orisakwe O.E., Afonne O.J., Ilondu N., Obi E., Ufearo C. S., Agbasi P. U., Maduka S. O., Orish C. N., Orish V.N. (2002). Influence of prokinetics on the gastrointestinal transit and residence times of activated charcoal. Journal of the Pakistan Medical Association. 52 (8) 354-358 (PAKISTAN).

70. Orisakwe O.E., Afonne O.J., Dioka C.E., Agbasi P.U., Obi E. (2002). Testicular toxicity of rinbacin in rats. Biol. Pharm. Bull. 25(2): 206-208 (JAPAN).

71. Afonne O.J., Orisakwe O.E., Ofoefule S.I., Tsalha S., Obi E., Ilondu N.A., Okorie O. (2002). Saline cathartics and adsorptive capacity of activated charcoal for doxycyline. Acta Poloniae Pharmaceutica Drug Research 59(3): 177-179 (POLAND).

72. Afonne O.J., Orisakwe O.E., Dioka C.E., Obi E., Ezejiofor T., Asomugha L., Ukoha U., (2002). Effects of rinbacin on rat kidney. Biol & Pharm Bull 25(8): 1022-1025 (JAPAN).

73. Dioka C.E., Orisakwe O.E., Afonne O.J., Agbasi P.U., Akumka DD., Okonkwo C.J., Ilondu N. (2002). Investigation into the haematologic and hepatic effects of rinbacin in rats. J Health Sci 48(5): 393-398 (JAPAN).

74. Afonne O.J. and Orisakwe O.E (1999) Cytokines in Environmental toxicology. Trop J Med. Res. (3) 1-8 (NIGERIA).

75. Orisakwe O.E., Afonne O.J., Chude M.A., Obi E., Ilondu N.A., Dioka C.E. (2003). Subchronic toxicity studies of the aqueous extract of Boerhavia diffusa leaves. J Health Sci 49(6) 444-447 (JAPAN)

76. Orisakwe O.E., Agbasi P.U., Afonne O.J., Orish C.N., Ilondu N.A., Obi E. (2004). Urinary excretion of rifampicin in the presence of ciprofloxacin. American J Ther. 11(3) 171-174 (USA)

77. Orisakwe O.E., Asomugha R., Obi E., Afonne O.J.,Anisi., Dioka C.E. (2004). Impact of effluents from car battery manufacturing plant on water, soil and food qualities in Nnewi, Nigeria. Arch. Environ. Health (Accepted for Publication) (USA).

78. Orisakwe O.E., Hussaini D.C., and Afonne O.J (2004) Testicular effects of sub-chronic adminustration of Hibiscus sabdariffa calyx aqueous extract in rats. Repro Tox. 18 (2) 295-298 (USA).

79. Dioka CE, Orisakwe OE ,Adeniyi FAA, and Meludu SC. (2004) Liver and renal function tests in occupationally lead exposed artisans in mechanic village in Nnewi, Nigeria. Int J Env Res & Pub Health 1 19-23 (USA).

80. Orisakwe O. E, Njan A A, Afonne O. J, AkumkA D. D, Orish V. N, Udemezue O. O (2004) Investigation into the Nephrotoxicity of Nigerian Bonny light Crude oil in Albino rats. Int J Env Res & Pub Health 2 ,91-95 (USA).

81. Orisakwe O.E., Afonne O.J., Ezejiofor N.A., Tsalha S. (2003). In vitro effects of sulphate cathartics on the adsorption of doxycycline to activated charcoal Eur Bull Drug Res 11 (4) 93-98 (Italy).

82. Orisakwe O.E., Hussaini D.C.,Orish V.N; Obi E; Udemezue .O., (2003) Nephrotoxic effects of Hibiscus sabdariffa calyx in rats Eur Bull Drug Res 11 (4) 99-104 (Italy).

83. Orisakwe O.E. E. Obi , V.N Orish, O.O. Udemezue (2003) Effect of halofantrine on testicular architecture and testosterone level in guinea pigs Eur Bull Drug Res 11 (4) 105-109 (Italy).

84. Orish.E .Orisakwe , Dora N. Akunyili ., Patrick.U Agbasi Ndidi.A. Ezejiofor (2003). Some plasma and saliva pharmacokinetics parameters of rifampicin in the presence of Pefloxacin American J Ther. 11 (4):283-287 (USA)

85. Orisakwe O.E., Akumka D.D., Njan A.A and Afonne O.J (2004). Testicular toxicity of Nigerian bonny-light crude oil in male albino rats. Repro Tox. 18 (3): 439-442 (USA)

86. Hussaini D. C, Orisakwe O. E , Njan A.A., Akumka D. D , Udemezue O. O, (2004) Subchronic administration of Nigerian specie of aqueous extract of hibiscus sabdariffa calyx in rats did not produce cardiotoxicity Eur Bull Drug Res 12 1-5 (Italy).

87. E. Obi, Orisakwe O.E., L. A Asomugha, V.N Orish, O.O. Udemezue and N.A. Ezejiofor (2004) Hepatotoxicity of halofantrine in guinea pigs Ind J Pharmac (Accepted for Publication) (INDIA)

88. Ifeyinwa C. Olife , Antoinette N.Okaka, Chudi E. Dioka, Samuel C. Meludu, Obi Ejeatuluchukwualo, Orish E. Orisakwe (2005). Iodine Status and effect of soil erosion on trace elements in Nanka and Oba towns of Anambra State, Nigeri Int J Env Res & Pub Health (Accepted for publication) (USA).

89. Rose Asomugha, Orish E. Orisakwe, Onyenmechi J. Afonne, Ejeatuluchukwu Obi, John C. Nduka, Chudi E. Dioka (2005). Impact of effluents from cable manufacturing plant on food, water and soil qualities in Nnewi, Nigeria. Pakistan J Biol Sci (Accepted for publication) (PAKISTAN).

90. O.E Orisakwe, D. D. Akumka, A. A. Njan, O. J. Afonne, O.O. Okechi (2005) Hepatotoxic and haematological effects of Nigerian bonny light crude oil in malealbino rat Toxicology and Environmental Chemistry (GERMANY)

91. Ilo.E.C, Orisakwe O.E , Ilondu N.A, Okwoli N , Brown S.A, Elo-Ilo J.C.(2005). Effect of Chloroquine on the bioavalability of ciprofloxacin in man. American J Ther (Accepted for publication) (USA).

PAPERS UNDER REVIEW

1. O.E.Orisakwe, E. Obi, D. N. Akunyili, B.O. Ekpo and H.M. Lantum (2004) Heavy metals hazards of Nigerian Herbal Remedies, Toxicologist (USA)

2. O.E.Orisakwe, E. Obi, J. Harry and Debem H (2005) Toxicologic pathology of halofantrine on guinea pig kidney Biomed Central Pharmac (USA)

3. Orisakwe O.E., Dioka C.E., and Adeniyi F.A.A. (2005) Zinc protection of testicular
toxicity of lead in guinea pig. Asian Journal of Andrology (CHINA)

4. O.E.Orisakwe, E. Obi , D. N. Akunyili (2005) Safety warnings and first aid instructions on Nigeria traditional herbal remedies: are they adequate? Clin Pharm Ther (USA)

5. Ilo ELO C, Orisakwe O.E , Ilondu N.A, Okwoli N , Brown S.A.( 2005) Urinary excretion pattern of Chloroquine and Ciprofloxacin when taken alone and in combination. Amer. J. Therap (USA).

6. ZETA-121 and Orisakwe O. E (2005) Labeling and certification on commonly consume beverages in Nigeria: are they adequate? . Amer. J. Therap (USA).

SOME RECENT CONFERENCE ABSTRACTS

1. Orisakwe O.E. et al (1995). Procedural update on laboratory diagnostic test and current treatment protocols for immunologically mediated infertility in the male. 21st Annual Scientific Conference of the Nigeria Society for Immunology. November 19 -22, 1995.

2. Orisakwe O.E. et al (1995). Therapeutic Challenges on HIV infections: A raging battle: Presented at the 21st Annual Scientific Conference of the Nigeria Society for Immunology November 19 -22, 1995.

3. Orisakwe O.E., Afonne O.J. (1997). Investigation into the effects of selenium and hexavalent chromium on murine testis. 24th Annual Regional Conference of the West African Society for Pharmacology (WASP).

4. Orisakwe O.E., Afonne O.J., Chilaka K.C., Obi E. (1998). Evaluation of the testicular toxicity of hexavalent chromium and effects of zinc 11 in mice. C0022. 19th Annual Meeting of SETAC. Charlotte NC.

5. Akumka D.D., Orisakwe O.E., Amos S., Ose J.T., Afonne O.J., Obi E., Gamaniel K.S. (1999). Does bonny light crude oil cause testicular toxicity? 26th Annual Regional Conference of the West African Society for Phamacolocology (WASP). Nsukka, Nigeria. October 20-23,1999.

6. Akumka D.D., Orisakwe O.E., Amos S., Ebute C.P., Afonne O.J., Adamu M., Njan A.A., Gamaniel K.S. (1999). Effect of bonny light crude oil on rat liver and liver enzymes. 26th Annual Regional Conference of the West African Society for Pharmacology (WASP). Nsukka, Nigeria. October 20-23,1999.

7. Pam H.C., Husaini D.C., Ajoku G., Orisakwe O.E., Gamaniel K.S. (2000). Some toxic effects of Hibiscus sabdariffa. 27th Annual Regional Conference of the West African Society for Phamacology (WASP). Port-Harcourt, Nigeria. October 23-28-2000.

8. Obi E., Orisakwe O.E., Odike M., Asomugha R., Asomugha L., Afonne O.J., Ilondu N.A., Agbasi P.U., Ukoha U. (2000). Toxicologic pathology of halofantine on guinea pig. 27th Annual Regional Conference of the West African Society for Pharmacology (WASP). Port-Harcourt, Nigeria. October 23-28, 2000.

9. Asomugha R., Asomugha L.A., Ukoha U., Maduka S.O., Orish V.N., Obi E., Afonne O.J., Orisakwe O.E. (2000). Splenic and haematologic effects of artesunate in guinea pig. 27th Annual Regional Conference of the West African Society for Pharmacology (WASP). Port-Harcourt, Nigeria. October 23-28, 2000.

10. Orisakwe O.E., Ilo E.C., Afonne O.J., Ofoefule S.I., Ilondu N.A., Agbasi P.U., Obi E., Maduka S.O. (2000). Effect of Chloroquine on the urinary excretion of ciprofloxacin. 27th Annual Regional Conference of the West African Society for Pharmacology (WASP). Port-Harcourt, Nigeria. October 23-28, 2000.

11. Husaini D.C., Pam H., Ukoha U., Afonne O.J., Orisakwe O.E., Gamaniel K.S. (2000). Hepatotoxicity study of Hisbiscus sabdariffa in rats. 27th Annual Regional Conference of the West African Society for Pharmacology (WASP). Port-Harcourt, Nigeria. October 23-28,2000.

12. Orisakwe O.E., Asomugha R., Afonne O.J., Obi E., Husaini D.C. (2001). Impact of effluents from lead battery and cable manufacturing plants on soil, water and food qualities. Environmental Health Conference, Ghana. January 3-6 2001.

13. Asomugha R., Orisakwe O.E., Afonne O.J., Obi E. (2001). Environmental effects of effluents from petroleum processing industry. Environmental Health Conference, Ghana. January 3-6, 2001.

14. Husaini D.C., Asomugha R., Orisakwe O.E. (2001). Impact of effluents from palm and kernel oil processing factory on water, soil and food qualities. Environmental Health Conference, Ghana. January 3-6, 2001.

15. Afonne O.J., Pam H.C., Orisakwe O.E. (2002). Health effects of exposure to some heavy metals in mechanic workshops. 29th Annual Regional Conference of the West African Society for Pharmacology (WASP). Abuja, Nigeria. October 21-23, 2002.

16. Orish E. Orisakwe and Ejeatulu Obi Heavy metal hazard of Nigerian traditional remedies 7th International International Society for the Study Xenobiotics meeting
Vancouver, Canada August 29- September 2, 2004

TECHNICAL REPORT SUBMITTED TO GOVERNMENT AGENCY IN NIGERIA.

ORISH EBERE ORISAKWE (2005). Report of study on evaluation of the medicinal role of locally produced carbon black

COURSES TAUGHT IN POSTGRADUATE (MSc)

1 . Pharmacokinetics PHA 700 3 Credits
2 . Neurotransmission and ANS PHA 701 4 Credits
3 . Immunopharmacology PHA 702 3 Credits
4 . CNS Pharmacology PHA 703 3 Credits
5 . Principles of Chemotherapy PHA 704 3 Credits
6 . Toxicology PHA 705 3 Credits
7 . Cardiovascular Pharmacology PHA 706 4 Credits
8 . Endocrine Pharmacology PHA 707 4 Credits
9 . Renal Pharmacology PHA 708 3 Credits
10. Seminar PHA 709 3 Credits
11. Research Project PHA 710 12 Credits

PhD COURSES TAUGHT.

1. Advances in Neuropharmacology PHA 803

2. Advances in Toxicology PHA 805

3. Advances in Chemotherapy PHA 806

MEMBERSHIP OF SENATE AND VICE CHANCELLOR’S COMMITTEES

1. Inaugural Lectures committee (Member); 2003-
2. International Linkage committee (Member); 2003-

CONTRIBUTION TO THE UNIVERSITY SYSTEM.

Introduction and Nurturing of Toxicology Unit.

Introduction and Nurturing of Animal House

Introduction and Nurturing of Postgraduate Programme

Organization of Toxicology Workshop On the Handling and Management   of Toxic Substance.

Organization of Toxicology Workshop on the Prevention and control   of AIDS.

Participated in the three (3)-tier accreditation in the College of   Health Sciences, Nnamdi Azikiwe University, Nnewi Campus.

Participated in the three (3)-tier accreditation in the College of Health Sciences, Abia State University, Uturu, Abia State.

Foundation Staff Pharmacology Dept., College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus.

Associate Lecturer, Pharmacology Dept., Abia State University Medical School, 1993-1997.

University Senator 1992-2000.

Faculty Examination Officer. 1992-1995.

External Examiner, Dept. of Pharmacology, Abia State University Medical School, 1998

Approved postgraduate degree supervisor.

Resource Person, University Committee on Staff Harmonization

Nominated four postgraduate students of Department of Pharmacology, Nnamdi Azikiwe University to the membership of ASTS who won four out of the five scholarship positions sponsored by the Third World Medical Foundation.

External Examiner, Department of Pharmacology, Ebonyi State University, 2000-.

External Examiner , Department of Pharmacology, University of Port HARCOURT, 2004-.

SERVICE TO THE COMMUNITY

Public Lecture/Workshop on Awareness of AIDS Prevention and Control.

Creation of Awareness on Living in a Chemical World.

Creation of Awareness on the Toxicology of Particulate Insults amongst Commercial Motorcyclists

REFEREES

Adebayo Oyekan DVM, PhD

Director, Center for Cardiovascular Diseases Research
College of Pharmacy and Health Sciences
Texas Southern University
3100 Cleburne Avenue
Houston TX 77004
Tel: 713 313 4258
Fax: 713 313 4342
E-mail: Oyekan_AO@TSU.edu

Dr Gerard M. Cooke
Health Canada,
Toxicology Research Division
Banting Research Centre
PL 2202D1 Tunney’s pasture
OTTAWA ON
K1A 0L2
E-mail: Gerard_ Cooke@hc-sc.gc.ca
Fax: (613) 941-6959

Hoffman Moka Lantum MD, PhD Toxicologist
Unit Director
Biochemical & Analytical Toxicology
Health and Environmental Laboratories
Eastman Kodak Company, USA.
E mail: hoffman.lantum@kodak.com


Chudy I. Nduaka DVM, PhD, DABT
President, African Education Initiative.
Email: chudy@nef3.org
www.nef3.org

Prof Jerome Nriagu
School of Public Health
Department of Environmental &Industrial Health
University of Michigan
USA
Email: jnriagu@sph.umich.edu

RECORDS OF SUPERVISION

NAME: OBI E.
TOPIC: Investigation into the Biochemical Basis of the Antiulcer Property of Synclisia scabrida (Miers)
DEGREE /DATE: MSc BIOCHEMISTERY 1997

NAME: AFONNE O. J.
TOPIC: Dose Zinc Protect Against Mercury-induced Testicular, Hepatic, Renal and
Splenic Damage in Mice?
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY, 1998

NAME: CHILAKA K.C.
TOPIC: Evaluation of Sub-Chronic and Developmental Toxicities of Amlodipine besylate in Mice.
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY, 1998

NAME: AKUMKA D. D.
TOPIC: Evaluation of the Testicular Toxicity of Bonny Light Crude Oil in Rats
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY /1999

NAME: NJAN A. A.
TOPIC: Nephrotoxicity and Hepatotoxicity of Bonny Light Crude Oil in Rats
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY/1999

NAME: ILONDU N. D. A.
TOPIC: Pharmacokinetics of Diethylcarbamazine: Prediction from Saliva Sample
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY/1999

NAME: ANUSIEM C.
TOPIC: Pharamacokinetics of New Fluoroquinolones
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY/1999

NAME: AGABSI P.U.
TOPIC: Influence of Ciprofloxacin and Pefloxacin on Rifampicin Pharmacokinetics.
DEGREE/DATE: MSc. PHARMACOLOGY & TOXICOLOGY/1999

NAME: CHUDE M.A.
TOPIC: Toxicological and Hypoglycaemic Effects of the Leaf Extract of Boerhevia diffusa in Rats
DEGREE/DATE: MSc PHARMACOLOGY & TOXICOLOGY/2000.

NAME: ILO ELO
TOPIC: Pharmacokinetic Drug Interactions of Chloroquine and Ciprofloxacin.
DEGREE/DATE: MSc. PHARMACOLOGY & TOXICOLOGY/2000

NAME: DIOKA CHUDI EMMA
TOPIC: Lead toxicity in occupationally exposed human subjects and the protective role of zinc in guinea pigs.
DEGREE/DATE: PhD Chemical Pathology, UNIVERSITY OF IBADAN, IBADAN
NIGERIA / 2003 (cosupervision).

NAME: OLIFE IFEYINWA CHIDIOGO.
TOPIC: Prevalence of iodine and some trace elements in some selected populations in Oba and Nanka, Anambra state Nigeria.
DEGREE/DATE: MSc Biochemistry, Nnamdi Azikiwe University, Awka/ 2004 (cosupervision).

ON-GOING SUPERVISIONS

NAME: Obi E
TOPIC: Investigation in to the male reproductive effects of Nigerian herbal remedies
DEGREE/DATE: PhD PHARMACOLOGY & TOXICOLOGY/2002-2005.

NAME: AFONNE O. J.
TOPIC:Investigations into the testicular mechanisms of Nigerian crude oil samples in male guinea pigs.
DEGREE/DATE: PhD PHARMACOLOGY & TOXICOLOGY, 2002-2005